Intermediate filaments in smooth muscle

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Intermediate filaments in smooth muscle.

The intermediate filament (IF) network is one of the three cytoskeletal systems in smooth muscle. The type III IF proteins vimentin and desmin are major constituents of the network in smooth muscle cells and tissues. Lack of vimentin or desmin impairs contractile ability of various smooth muscle preparations, implying their important role for smooth muscle force development. The IF framework ha...

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Invited Review Intermediate filaments in smooth muscle

Tang DD. Intermediate filaments in smooth muscle. Am J Physiol Cell Physiol 294: C869–C878, 2008. First published February 6, 2008; doi:10.1152/ajpcell.00154.2007.— The intermediate filament (IF) network is one of the three cytoskeletal systems in smooth muscle. The type III IF proteins vimentin and desmin are major constituents of the network in smooth muscle cells and tissues. Lack of vimenti...

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Intermediate filaments in smooth muscle tumours.

Antisera to the intermediate filaments vimentin and desmin react with fixed paraffin embedded tissue. Benign uterine myomas contain both classes of filaments. Gastrointestinal "smooth muscle tumours" however often lack desmin even when they appear histologically benign. In the sarcomas examined vimentin was the only class of intermediate filament present. The diagnostic and histogenetic implica...

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Hypertrophy-induced increase of intermediate filaments in vascular smooth muscle

The distribution of filaments was studied in hypertrophied rabbit vascular smooth muscle. Hypertrophy was induced by partial ligation of the portal-anterior mesenteric vein. 14 d after ligation, there was an approximately threefold increase in the number of intermediate filaments per cross-sectional area, as compared to control values. The actin:intermediate:myosin filament ratio was 15:1.1:1 i...

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Localization of Myosin Filaments in Smooth Muscle

Thick myosin filaments, in addition to actin filaments, were found in sections of glycerinated chicken gizzard smooth muscle when fixed at a pH below 6.6. The thick filaments were often grouped into bundles and run in the longitudinal axis of the smooth muscle cell. Each thick filament was surrounded by a number of thin filaments, giving the filament arrangement a rosette appearance in cross-se...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Cell Physiology

سال: 2008

ISSN: 0363-6143,1522-1563

DOI: 10.1152/ajpcell.00154.2007